How genes shape brain network communication in PTSD
Genomic Architecture of Functional Brain Networks in PTSD
This project looks at how genetic differences affect brain communication patterns linked to PTSD to help people with trauma-related symptoms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11249536 on NIH RePORTER |
What this research studies
If I took part, researchers would combine resting-state brain scans (fMRI) with genetic data to see which genes relate to changes in key brain networks tied to PTSD symptoms. They will focus on networks like the default mode, salience, and attention networks and compare connectivity patterns in people with and without PTSD. The team will use large datasets and genetic analyses to map the neurogenetic pathways that might make someone more likely to develop persistent trauma symptoms. The goal is to connect brain communication measures with inherited genetic factors to guide future targeted treatments.
Who could benefit from this research
Good fit: Ideal participants are adults with a history of trauma and current or past PTSD who can give a DNA sample and undergo MRI scanning.
Not a fit: People without PTSD, those unwilling to provide genetic samples or have an MRI, or those seeking immediate treatment changes are unlikely to get direct benefit from participating.
Why it matters
Potential benefit: If successful, this work could reveal biological targets for more personalized treatments or new medications for PTSD.
How similar studies have performed: Previous studies show PTSD is linked to altered brain networks and that these connectivity traits are partly heritable, but combining large-scale genetics with resting-state fMRI in PTSD is still an emerging approach.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Morey, Rajendra a — Duke University
- Study coordinator: Morey, Rajendra a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.