How genes guide cell development and identity
Defining gene regulatory networks controlling cell fate
This project helps us understand how genes tell cells what to do and become, which is important because these instructions can go wrong in many illnesses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11115643 on NIH RePORTER |
What this research studies
Our cells have intricate instruction manuals, called gene regulatory networks, that tell them what job to do and how to behave. These networks are crucial for healthy cell function, but when they go awry, they can contribute to many diseases. This project aims to map out these complex instructions by using advanced single-cell technologies that look at thousands of individual cells. We are developing new computer tools to understand how these networks are organized and how they change, which is a big challenge in biology.
Who could benefit from this research
Good fit: This foundational research is relevant for anyone interested in the basic biological mechanisms that contribute to various human diseases.
Not a fit: Patients seeking immediate new treatments or clinical trial opportunities will not directly benefit from this foundational research.
Why it matters
Potential benefit: If successful, this work could provide a fundamental understanding of how diseases develop at the cellular level, potentially leading to new ways to identify and treat them.
How similar studies have performed: This project builds on existing single-cell omics technologies but aims to develop novel computational methods for integrating complex data, representing a new approach to network inference.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Roy, Sushmita — University of Wisconsin-Madison
- Study coordinator: Roy, Sushmita
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.