How genes, environment, and gut bacteria affect type 2 diabetes and metabolic syndrome
Official title: Interaction between genes, environment, the microbiome and metabolome in type 2 diabetes and metabolic syndrome
Funded at Joslin Diabetes Center · NIH-10786111 · Data updated 2026-11-12
This study is looking at how our genes, the environment we live in, and the bacteria in our gut all work together to affect the risk of developing type 2 diabetes and related health issues, using mice to see how changes in these areas can help us find better ways to treat diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Joslin Diabetes Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 1, 2020 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $526,942 |
| NIH project number | 5R01DK121967-05 |
| Project ID | NIH-10786111 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for or diagnosed with type 2 diabetes or metabolic syndrome.
✕Less likely to help
Patients who do not have type 2 diabetes or metabolic syndrome, or those with other unrelated metabolic disorders, may not benefit from this research.
What this research studies
This research investigates the complex interactions between genetics, environmental factors, and the gut microbiome in the development of type 2 diabetes and metabolic syndrome. By using different strains of laboratory mice, the study aims to understand how these factors contribute to insulin resistance and obesity. The researchers will manipulate the microbiome through environmental changes and antibiotic treatments to observe their effects on metabolic health. This approach could provide insights into personalized treatment strategies for diabetes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and managing type 2 diabetes and metabolic syndrome by targeting the microbiome.
How similar studies have gone: Previous research has shown promising results in understanding the role of the microbiome in metabolic health, indicating that this approach could yield valuable insights.
Where this research is happening
-
Joslin Diabetes Center
Boston, United States Active
Researchers
- Principal investigator: Kahn, C Ronald — Joslin Diabetes Center
- Study coordinator: Kahn, C Ronald
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.