How genes control tiny cellular antennae called cilia
Genetic analysis of signaling pathways in cilia assembly and remodeling
['FUNDING_OTHER'] · WORCESTER POLYTECHNIC INSTITUTE · NIH-11321247
This project looks at how genes and signaling pathways shape and reshape tiny cellular antennae called cilia, with relevance for people who have ciliopathy-related conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WORCESTER POLYTECHNIC INSTITUTE (nih funded) |
| Locations | 1 site (WORCESTER, UNITED STATES) |
| Trial ID | NIH-11321247 on ClinicalTrials.gov |
What this research studies
The team uses tiny roundworms (C. elegans) and complementary mammalian cell models to follow cilia assembly and remodeling at single-cell resolution. They combine molecular genetics, proteomics, and live imaging to identify genes and signaling networks that control cilia shape and function. A major focus is on how heterotrimeric G proteins and GPCR-related mechanisms are trafficked to and act within cilia. The researchers also examine how environmental stress triggers structural changes in cilia and alters signaling output.
Who could benefit from this research
Good fit: People with inherited ciliopathies or genetic variants known to affect cilia structure or signaling would be most relevant to this research.
Not a fit: Patients whose conditions are unrelated to cilia biology or who need immediate clinical treatment are unlikely to benefit directly from this basic lab-based work.
Why it matters
Potential benefit: If successful, this work could reveal genes and pathways that become targets for future diagnostics or therapies for ciliopathies and related disorders.
How similar studies have performed: Many prior studies in model organisms and cell lines have advanced basic cilia biology, but translating those findings into therapies has been limited and remains an ongoing challenge.
Where this research is happening
WORCESTER, UNITED STATES
- WORCESTER POLYTECHNIC INSTITUTE — WORCESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NECHIPURENKO, INNA — WORCESTER POLYTECHNIC INSTITUTE
- Study coordinator: NECHIPURENKO, INNA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.