How genes control the timing of development in simple animals
Genetic control of developmental timing
['FUNDING_OTHER'] · UNIV OF MASSACHUSETTS MED SCH WORCESTER · NIH-11011810
This study is exploring how tiny molecules in worms help control when their cells change and grow, which could teach us how animals adapt to different environments as they develop.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF MASSACHUSETTS MED SCH WORCESTER (nih funded) |
| Locations | 1 site (WORCESTER, UNITED STATES) |
| Trial ID | NIH-11011810 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic regulatory networks that dictate the timing of developmental events in multicellular organisms, focusing on the nematode Caenorhabditis elegans. By examining how microRNAs and other regulators influence the robustness of development, the research aims to understand how animals adapt to environmental stresses during their growth. The study specifically looks at heterochronic genes that control when cells change their fate during larval development, providing insights into the mechanisms behind cellular proliferation and differentiation.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with genetic developmental disorders or those interested in the mechanisms of cellular growth and differentiation.
Not a fit: Patients with conditions unrelated to genetic developmental timing or those not affected by cellular proliferation issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to advancements in understanding developmental disorders and improving regenerative medicine.
How similar studies have performed: Previous research has shown success in understanding genetic control of development in model organisms, suggesting that this approach could yield valuable insights.
Where this research is happening
WORCESTER, UNITED STATES
- UNIV OF MASSACHUSETTS MED SCH WORCESTER — WORCESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AMBROS, VICTOR — UNIV OF MASSACHUSETTS MED SCH WORCESTER
- Study coordinator: AMBROS, VICTOR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.