How genes control the SYK protein involved in allergies
Genetic Control of the SYK Tyrosine-protein Kinase in Allergy
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-11284103
This work looks at how genetic differences change the amount and activity of the SYK protein in people with IgE-driven allergic conditions like asthma.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11284103 on ClinicalTrials.gov |
What this research studies
You would be hearing about research that studies how small genetic changes near the SYK gene affect SYK levels in immune cells called basophils and how that links to histamine release and allergy symptoms. The team analyzes human genetic variants (SNPs) and cis-eQTLs alongside lab tests of basophil SYK expression and IgE-mediated histamine release. They will connect those genetic and cellular findings to clinical signals, including prior basophil markers that predicted response to the allergy drug omalizumab. The work is carried out at Johns Hopkins using human samples and laboratory assays.
Who could benefit from this research
Good fit: People with IgE-mediated allergic diseases, such as allergic asthma or other atopic conditions, would be the most relevant candidates for this work.
Not a fit: People whose symptoms are not driven by IgE-mediated allergy or who need immediate treatment rather than diagnostic or predictive genetic information may not see direct benefit.
Why it matters
Potential benefit: If successful, this could identify genetic biomarkers that help predict who will respond to specific allergy treatments and guide more personalized care.
How similar studies have performed: Prior studies have linked SYK activity and basophil markers to IgE-mediated allergy and shown such markers can help predict response to drugs like omalizumab, but the genetic regulation of SYK remains less well understood.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GAO, LI — JOHNS HOPKINS UNIVERSITY
- Study coordinator: GAO, LI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Allergic Disease