How genes are regulated during the division of stem cells
Mechanisms of Gene Regulation During Asymmetric Stem Cell Division
['FUNDING_OTHER'] · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · NIH-11129686
This study looks at how certain genes work during the special way stem cells divide, focusing on fruit fly male stem cells, to better understand how these cells change and develop into different types of cells.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CONNECTICUT SCH OF MED/DNT (nih funded) |
| Locations | 1 site (FARMINGTON, UNITED STATES) |
| Trial ID | NIH-11129686 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms of gene regulation during the asymmetric division of stem cells, specifically focusing on Drosophila male germline stem cells. By examining how homologous chromosomes interact and pair during cell division, the study aims to understand the changes in gene expression that occur as stem cells differentiate. The research utilizes advanced genetic techniques to observe the behavior of specific genes and their chromatin states in real-time, providing insights into the fundamental processes of cellular differentiation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to stem cell function or differentiation, including certain types of cancer.
Not a fit: Patients with conditions unrelated to stem cell biology or those who do not have a genetic component to their disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for manipulating stem cell behavior, which may improve treatments for various cancers and regenerative medicine.
How similar studies have performed: Previous studies have shown promising results in understanding gene regulation through similar mechanisms in other model organisms, indicating a potential for success in this area.
Where this research is happening
FARMINGTON, UNITED STATES
- UNIVERSITY OF CONNECTICUT SCH OF MED/DNT — FARMINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: INABA-OGURO, MAYU — UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
- Study coordinator: INABA-OGURO, MAYU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers