How genes and the gut environment shape IBD symptoms
Determining genomic and host-environment contributions to IBD phenotypes
['FUNDING_U01'] · CEDARS-SINAI MEDICAL CENTER · NIH-11137812
This project looks at how people's genes and gut microbes influence Crohn's disease and ulcerative colitis to help improve treatment choices.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CEDARS-SINAI MEDICAL CENTER (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11137812 on ClinicalTrials.gov |
What this research studies
If you join, researchers will collect clinical information, blood, and stool samples from people with Crohn's disease or ulcerative colitis across the U.S. They will compare DNA across diverse populations and study how host genes interact with the gut microbiome. Scientists will measure gene and protein activity, including in single cells from blood and the gut lining, to link molecular patterns to symptoms and treatment response. The team will especially try to explain why some people do not respond to common biologic therapies and test the functional effects of specific genetic changes.
Who could benefit from this research
Good fit: Adults with Crohn's disease or ulcerative colitis, especially those with diverse ancestry or who have had limited response to biologic treatments, and who can provide blood, stool, and clinical information.
Not a fit: People without IBD or those seeking immediate changes to their medical treatment are unlikely to receive direct benefit from participating.
Why it matters
Potential benefit: Could enable more personalized IBD care and better prediction of who will benefit from specific biologic therapies.
How similar studies have performed: Previous genetics and microbiome work has identified risk genes and microbial links but translating those findings into reliable clinical tests or treatments has been limited so far.
Where this research is happening
LOS ANGELES, UNITED STATES
- CEDARS-SINAI MEDICAL CENTER — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MCGOVERN, DERMOT PATRICK — CEDARS-SINAI MEDICAL CENTER
- Study coordinator: MCGOVERN, DERMOT PATRICK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.