How genes and environment affect early embryo development
Epigenetic and environmental impact on early embryonic development
['FUNDING_OTHER'] · YALE UNIVERSITY · NIH-11144798
This study is looking at how genes and the environment work together to help embryos grow and develop, which could give us important clues about birth defects and help improve our understanding of early development.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11144798 on ClinicalTrials.gov |
What this research studies
This research investigates how both genetic factors and environmental influences shape the development of embryos. By examining the complex interactions between transcription factors and chromatin modifications, the study aims to understand how these processes contribute to cellular diversity during early development. The researchers will use advanced techniques such as micromanipulation and single-cell analysis to gather detailed information about mutant embryos, which could help clarify the mechanisms behind congenital disorders. This approach is designed to provide insights that are not achievable through traditional cell line studies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of congenital disorders or those who are pregnant and concerned about the health of their developing embryos.
Not a fit: Patients who are not pregnant or do not have a family history of congenital disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of congenital disorders and improved strategies for prevention or treatment.
How similar studies have performed: Other research has shown success in understanding genetic and environmental impacts on development, but this approach is innovative and aims to provide new insights into embryonic development.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SMITH, ZACHARY DYLAN — YALE UNIVERSITY
- Study coordinator: SMITH, ZACHARY DYLAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.