How genes and environment affect DNA changes and aging in twins
Cytosolic DNA, Telomeres/Subtelomeres, and Epigenetics: A Longitudinal Twin Study to Assess the Role of Genetics and Environment on their Frequency and Inter-relationships
This research looks at how our genes and surroundings influence tiny DNA changes in our cells, called cytosolic DNA, and how these changes relate to aging in twins.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project ID | NIH-11123406 on NIH RePORTER |
What this research studies
We are following 100 pairs of twins over 10 to 15 years to understand why some people develop certain DNA changes in their cells as they age. By studying both identical and fraternal twins, we hope to learn if these changes are mostly due to genetics or environmental factors. We will collect blood and cheek cell samples at different times to measure specific DNA markers, including telomere lengths and DNA methylation patterns, alongside the cytosolic DNA levels. This will help us see how these different aging signs develop together over time.
Who could benefit from this research
Good fit: This study is specifically designed for identical and fraternal twin pairs, currently ranging in age from 22 to over 80 years old.
Not a fit: Individuals who are not part of a twin pair would not be eligible for direct participation in this specific research.
Why it matters
Potential benefit: If successful, this work could help us better understand the fundamental processes of aging and identify early markers that might predict age-related health issues.
How similar studies have performed: This research uses a novel assay developed by the researchers to measure specific DNA changes, building on existing knowledge about aging biomarkers.
Where this research is happening
Richmond, United States
- Virginia Commonwealth University — Richmond, United States (Active)
Researchers
- Principal investigator: Jackson-Cook, Colleen K — Virginia Commonwealth University
- Study coordinator: Jackson-Cook, Colleen K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.