How genes affect brain development and function
Neurodevelopmental Disorder Risk Gene Regulation of Intrinsic Membrane Excitability: A Rheostat that Tunes Dendritic Morphogenesis to Regulate Circuit Assembly During Development
This study is looking at how certain genes affect the way brain circuits develop, especially in the part of the brain that helps with thinking, to better understand neurodevelopmental disorders that can happen when these genes don't work right.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10876345 on NIH RePORTER |
What this research studies
This research investigates how specific genes influence the development of neural circuits in the brain, particularly in the cerebral cortex. By examining gene expression during critical developmental stages, the project aims to uncover the biological processes that lead to proper brain wiring and function. The researchers will focus on neurodevelopmental disorders, which can arise from genetic mutations that disrupt normal circuit formation. Through advanced techniques, they will explore how these genes regulate the electrical properties of neurons, which is essential for healthy cognitive function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodevelopmental disorders or those at risk due to genetic factors.
Not a fit: Patients with neurodevelopmental disorders not linked to genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the causes of neurodevelopmental disorders and inform potential therapeutic strategies.
How similar studies have performed: Other research has shown promising results in understanding gene functions related to brain development, indicating that this approach has potential for significant findings.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Rumbaugh, Gavin R — University of Florida
- Study coordinator: Rumbaugh, Gavin R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.