How genes affect blood clotting proteins (factor VIII and von Willebrand factor)
Analysis of Whole Genome Sequence and Hemostasis Phenotypes
Researchers are looking at how people's genes relate to levels of two blood-clotting proteins, with a focus on Hispanic adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11126733 on NIH RePORTER |
What this research studies
This project measures levels of factor VIII and von Willebrand factor in blood samples and links those measurements to whole genome sequencing data. The team will analyze samples from about 14,000 Hispanic participants and include multi-ancestry data to find new genetic regions that change protein levels. They will use advanced genetics approaches, including studying gene-gene interactions and epigenetic signals, to understand how these factors influence blood clots, heart attack, and stroke risk. The work aims to separate effects that act on one protein versus both proteins to clarify pathways that might lead to thrombotic disease.
Who could benefit from this research
Good fit: Adults who can give a blood sample and share genetic data—especially people of Hispanic ancestry—are the most relevant candidates to participate or contribute samples.
Not a fit: People needing immediate clinical treatment for bleeding or clotting problems or those unwilling to share genetic data are unlikely to get direct benefit from this observational genetics project.
Why it matters
Potential benefit: If successful, the work could improve prediction of who is at higher risk for dangerous blood clots and point to new prevention or treatment targets.
How similar studies have performed: Previous genome-wide studies have already identified genetic loci tied to FVIII and VWF levels and used Mendelian randomization to link them to clotting diseases, but this project expands to understudied populations and epigenetic and interaction mechanisms.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Morrison, Alanna C — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Morrison, Alanna C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.