How gene regulation affects heart function and repair
Impacts of transcription elongation on cardiac gene regulation during homeostasis and regeneration
This study is looking at how a protein called Rtf1 helps keep the heart working well and heal after injury, using zebrafish and mice to learn more about heart failure and find new ways to treat heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10753509 on NIH RePORTER |
What this research studies
This research investigates the role of a specific transcription regulator, Rtf1, in maintaining heart function and promoting repair after injury. By studying both zebrafish and mouse models, the researchers aim to understand how changes in gene expression during heart failure can lead to structural and functional defects. The project focuses on the mechanisms of transcription elongation and its impact on cardiac health, with the goal of identifying potential therapeutic targets for heart disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults with heart failure or those at risk of developing heart-related conditions.
Not a fit: Patients with non-cardiac related health issues or those without heart failure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and recovery in patients with heart failure.
How similar studies have performed: Previous research has shown promising results in understanding gene regulation in cardiac biology, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Chen, Jau-Nian — University of California Los Angeles
- Study coordinator: Chen, Jau-Nian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.