How gene-regulating condensates drive multiple myeloma
Project 2: Investigating regulation of transcriptional condensates in multiple myeloma
This work looks at how tiny cellular droplets that control genes help multiple myeloma grow and change how cancer drugs work.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11179321 on NIH RePORTER |
What this research studies
This project studies ‘transcriptional condensates’ — tiny droplets inside myeloma cells that concentrate proteins, RNA, and the machinery that turns genes on. Researchers use biochemical tests, high-resolution imaging, and tumor-derived cell samples to see how these condensates form and how they alter oncogene activity. They are testing how changing condensate chemistry affects gene activity and the local concentration and effects of anti-cancer drugs. Some experiments use patient-derived myeloma cells at Dana‑Farber/Whitehead to move these lab findings toward therapies.
Who could benefit from this research
Good fit: People with multiple myeloma who are willing to donate tumor samples or participate in early translational trials at Dana‑Farber may be eligible.
Not a fit: People without multiple myeloma, or those whose disease is driven by other mechanisms, are unlikely to benefit directly from this work.
Why it matters
Potential benefit: Could lead to new drugs or ways to make existing drugs work better against multiple myeloma.
How similar studies have performed: Laboratory studies have shown condensates control oncogene activity and can concentrate drugs, but translating these findings into treatments is still novel and unproven.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: Young, Richard — Dana-Farber Cancer Inst
- Study coordinator: Young, Richard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.