How gene expression is controlled by different mRNA forms
Official title: Regulation of gene expression by alternative polyadenylation
Funded at Wistar Institute · NIH-11061218 · Data updated 2026-11-12
This study looks at how changes in a process called alternative polyadenylation can affect how genes make different versions of proteins, especially when cells are under stress or growing, to help us understand how cells adjust to their surroundings.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wistar Institute NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $664,842 |
| NIH project number | 5R35GM153277-02 |
| Project ID | NIH-11061218 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve altered gene expression, such as cancer or metabolic disorders.
✕Less likely to help
Patients with stable gene expression profiles or those not affected by cellular stress or differentiation may not benefit from this research.
What this research studies
This research investigates how alternative polyadenylation (APA) affects gene expression by producing different forms of mRNA that can lead to varied protein production. By examining how these mRNA isoforms change in response to different cell conditions, such as stress or growth, the research aims to uncover the underlying mechanisms of gene regulation. The team uses a combination of molecular biology techniques, functional genomics, and computational analysis to explore these processes across various cell types and conditions. The findings could provide insights into how cells adapt to their environments and how gene expression is finely tuned.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases by targeting the mechanisms of gene regulation.
How similar studies have gone: Previous research has shown promising results in understanding gene regulation through similar approaches, indicating that this area of study is both relevant and potentially impactful.
Where this research is happening
-
Wistar Institute
Philadelphia, United States Active
Researchers
- Principal investigator: Tian, Bin — Wistar Institute
- Study coordinator: Tian, Bin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.