How gene expression affects long-term memory formation and persistence
Transcriptomic Mechanisms of Formation and Persistence of Synapse Specific Long-Term Memory
This study is looking at how certain genes in brain cells help us form and keep long-term memories, using a sea snail as a model, to better understand the science behind memory.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10704035 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms behind long-term memory (LTM) by examining how gene expression changes in specific neurons contribute to the formation and maintenance of memories. Using the marine snail Aplysia californica, the study focuses on the neural circuitry involved in the gill-withdrawal reflex, a well-understood model for learning. Researchers will analyze the transcriptomic changes in both pre-synaptic and post-synaptic neurons to understand how these changes facilitate memory storage. The goal is to uncover the specific genes and molecular processes that are essential for the persistence of LTM.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research would include individuals with memory disorders or cognitive retention issues.
Not a fit: Patients with acute memory loss due to trauma or those not experiencing cognitive retention disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into memory disorders and potential therapeutic targets for improving cognitive retention.
How similar studies have performed: Other research has shown promising results in understanding memory mechanisms through similar approaches, but this specific focus on transcriptomic changes in Aplysia is relatively novel.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Puthanveettil, Sathya — University of Florida
- Study coordinator: Puthanveettil, Sathya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.