How gastrin affects stomach stem cells and their growth
Gastrin Regulation of Gastric Antral Stem and Corpus Progenitor Cells
This study is looking at how a special receptor in the stomach, called Cck2r, helps control the growth and behavior of stomach stem cells, which could help us learn more about stomach health and diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10912614 on NIH RePORTER |
What this research studies
This research investigates the role of the gastrin receptor, Cck2r, in regulating the behavior of stomach stem cells and progenitor cells. It aims to understand how gastrin influences these cells' growth and division, particularly in response to different signals and conditions. By using both laboratory techniques and animal models, the study will explore how gastrin affects the proliferation of these cells, which could have implications for understanding stomach health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting the stomach, particularly those related to gastrin signaling or gastric cell proliferation.
Not a fit: Patients with non-gastric related conditions or those not affected by gastrin signaling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into stomach cell behavior, potentially improving treatments for gastric diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of gastrin in gastric cell behavior, indicating that this approach has potential for success.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Wang, Timothy Cragin — Columbia University Health Sciences
- Study coordinator: Wang, Timothy Cragin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.