How gammaherpesvirus affects B cell infections and lymphoma development
Gammaherpesvirus miRNA suppression of EWSR1 in GC B cell infection and lymphomagenesis
This study is looking at how certain viruses, like Epstein-Barr and Kaposi’s sarcoma-associated herpesvirus, might contribute to the development of B cell lymphomas, with the hope of finding new ways to treat these cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10887433 on NIH RePORTER |
What this research studies
This research investigates the role of gammaherpesviruses, specifically Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus, in the development of B cell lymphomas. It focuses on how these viruses manipulate germinal center reactions in B cells, leading to malignancies. The study utilizes a related murine virus to explore the functions of virus-encoded microRNAs and their impact on a host protein called EWSR1, which is crucial for understanding the biology of these infections and their contribution to cancer. By examining these mechanisms, the research aims to uncover potential therapeutic targets for treating related lymphomas.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with or at risk for B cell lymphomas linked to gammaherpesvirus infections.
Not a fit: Patients with non-B cell malignancies or those not infected with gammaherpesviruses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating B cell lymphomas associated with gammaherpesvirus infections.
How similar studies have performed: Other research has shown promising results in understanding the role of viral microRNAs in cancer, suggesting that this approach may yield valuable insights.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Tibbetts, Scott a. — University of Florida
- Study coordinator: Tibbetts, Scott a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.