How galectins affect immune responses in allergic diseases
Galectins in Modulating Immune Responsiveness of IgE-bearing Cells
This study is looking at how certain proteins called galectins affect the immune cells that play a big role in allergies, like asthma and food allergies, to help find new ways to treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10843951 on NIH RePORTER |
What this research studies
This research investigates the role of galectins in modulating the immune responses of IgE-bearing cells, which are crucial in allergic diseases like asthma and food allergies. By examining how these proteins interact with basophils and other immune cells, the study aims to uncover mechanisms that lead to allergic reactions. The approach includes using mouse models and human cell cultures to explore the activation pathways of basophils and their response to allergens. This could provide insights into new therapeutic targets for managing allergic conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with allergic diseases, particularly those with asthma or food allergies.
Not a fit: Patients without allergic conditions or those who do not have IgE-mediated responses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for allergic diseases, improving the quality of life for patients suffering from conditions like asthma.
How similar studies have performed: Other research has shown promising results in understanding immune responses in allergic diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Schroeder, John T. — Johns Hopkins University
- Study coordinator: Schroeder, John T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.