How fungal imbalances affect pneumonia after influenza
Fungal dysbiosis regulation of post-influenza bacterial pneumonia
['FUNDING_R01'] · CEDARS-SINAI MEDICAL CENTER · NIH-10871711
This study is looking at how taking antibiotics when you have the flu might upset the balance of fungi in your body, which could increase the chances of getting a serious lung infection, and it involves patients sharing samples to help us understand this better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CEDARS-SINAI MEDICAL CENTER (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10871711 on ClinicalTrials.gov |
What this research studies
This research investigates how the use of antibiotics during influenza infections can lead to an imbalance of fungal organisms in the body, which may worsen the risk of developing secondary bacterial pneumonia. By examining the interactions between the microbiome and the immune system, the study aims to understand the role of fungal dysbiosis in this process. The approach includes analyzing patient samples and conducting experiments to identify the mechanisms behind these changes. Patients may be involved in providing samples or data to help elucidate these relationships.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have recently experienced influenza infections and are at risk for developing secondary bacterial pneumonia.
Not a fit: Patients who have not had influenza or those with pre-existing severe respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that minimize the risk of pneumonia in patients recovering from influenza.
How similar studies have performed: Previous research has indicated that alterations in the microbiome can significantly impact health outcomes, suggesting that this approach may yield valuable insights.
Where this research is happening
LOS ANGELES, UNITED STATES
- CEDARS-SINAI MEDICAL CENTER — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, PETER — CEDARS-SINAI MEDICAL CENTER
- Study coordinator: CHEN, PETER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.