How frustration affects drug-taking behavior

Frustration effects on drug taking

NIH-funded research University of Texas Med Br Galveston · NIH-11064895

This study looks at how feeling frustrated might affect teenagers' desire to use drugs by observing rat behavior, hoping to learn more about how early experiences with frustration can influence their choices around substance use.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Texas Med Br Galveston NIH-funded
Lab location1 site (Galveston, United States)
Project IDNIH-11064895 on NIH RePORTER

What this research studies

This research investigates the role of frustration in influencing motivation for drug use, particularly in adolescents. By studying rat behavior, the researchers aim to understand how frustration can either decrease or fail to decrease the motivation for substance use disorders. The project will utilize specific behavioral tests to measure how frustration impacts drug-seeking behavior and identify the neurobiological mechanisms involved. The findings could provide insights into how early life experiences shape individual responses to frustration and drug motivation.

Who could benefit from this research

Good fit: Ideal candidates for this research are adolescents aged 12 to 20 who may be at risk for substance use disorders.

Not a fit: Patients outside the age range of 12 to 20 or those not experiencing issues related to substance use may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to new strategies for preventing and treating substance use disorders in adolescents.

How similar studies have performed: Previous research has shown that understanding behavioral responses to frustration can inform treatment approaches for substance use disorders, indicating that this area of study has potential for impactful findings.

Where this research is happening

Galveston, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.