How fructose affects the survival of colorectal cancer cells
Molecular Mechanisms of Fructose-induced Colorectal Cancer Cell Survival
This study is looking at how eating too much fructose might affect colorectal cancer and whether a certain enzyme helps cancer cells grow, with the hope of finding new ways to treat this type of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11001830 on NIH RePORTER |
What this research studies
This research investigates the link between fructose consumption and colorectal cancer, focusing on how fructose may promote cancer cell survival. The team will explore the role of a specific enzyme, ketohexokinase, and its product, fructose 1-phosphate, in enhancing tumor growth. Using mouse models and human cell cultures, they will manipulate metabolic pathways to understand how fructose influences cancer cell behavior. The goal is to uncover the molecular mechanisms that could lead to new treatment strategies for colorectal cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 who have a history of colorectal cancer or are at high risk due to dietary factors.
Not a fit: Patients who do not consume fructose or have no risk factors for colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into colorectal cancer treatment and prevention strategies related to dietary choices.
How similar studies have performed: While the specific mechanisms of fructose's impact on colorectal cancer are still being explored, previous studies have shown that dietary factors can significantly influence cancer progression, suggesting potential for success in this area.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Goncalves, Marcus Dasilva — New York University School of Medicine
- Study coordinator: Goncalves, Marcus Dasilva
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.