How Francisella tularensis invades red blood cells and its role in disease spread
The mechanism and role of erythrocyte invasion by Francisella tularensis
This study is looking at how the bacteria that cause tularemia get into red blood cells and what that means for how the disease spreads, which could help us find better ways to prevent and treat infections for people at risk.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | West Liberty University NIH-funded |
| Lab location | 1 site (West Liberty, United States) |
| Project ID | NIH-10730228 on NIH RePORTER |
What this research studies
This research investigates how the bacterium Francisella tularensis, which causes the severe disease tularemia, invades red blood cells (erythrocytes) and the implications of this invasion for disease transmission. The study focuses on understanding the interactions between the bacteria and various cell types, particularly erythrocytes, which may help the bacteria survive in ticks, a key vector for spreading the disease. By exploring the mechanisms of erythrocyte invasion, the research aims to uncover new insights into the pathogenesis of tularemia and its transmission dynamics. This could lead to better strategies for preventing and treating infections caused by this highly infectious organism.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who may be at risk for tularemia, particularly those with exposure to ticks or environments where the bacterium is prevalent.
Not a fit: Patients who are not at risk for tularemia or have no exposure to the bacterium are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for tularemia, potentially reducing the incidence of this serious disease.
How similar studies have performed: While the specific focus on erythrocyte invasion by Francisella tularensis is novel, previous research has shown success in understanding bacterial interactions with host cells, indicating potential for impactful findings.
Where this research is happening
West Liberty, United States
- West Liberty University — West Liberty, United States (Active)
Researchers
- Principal investigator: Horzempa, Joseph a — West Liberty University
- Study coordinator: Horzempa, Joseph a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.