How frailty affects the effectiveness of influenza vaccination in older adults

Who could benefit from this research

What this research studies

This research investigates the relationship between frailty and the effectiveness of influenza vaccination among older adults, particularly focusing on community-dwelling Veterans and those in Community Living Centers. It aims to assess whether frailty, measured using the VA Frailty Index, influences vaccine effectiveness and outcomes after vaccination. By understanding these links, the research seeks to improve vaccination strategies for older adults who are at higher risk of severe outcomes from influenza. The study will utilize electronic assessments and analyze data to draw meaningful conclusions.

Why it matters

Where this research is happening

• VA Greater Los Angeles Healthcare System
  Los Angeles, United States Active

Researchers

• Principal investigator: Seligman, Benjamin Joseph — VA Greater Los Angeles Healthcare System
• Study coordinator: Seligman, Benjamin Joseph

Related research

Other NIH-funded projects on the same topics.

• Frailty and Flu Vaccination in Older Adults

  This project studies how frailty in older adults affects how well the flu vaccine works and how likely they are to have good outcomes after vaccination.

  NIH research VA Greater Los Angeles Healthcare System · Los Angeles, United States · NIH-11287885

• How frailty affects flu vaccination outcomes in older adults

  This study is looking at how being frail affects how well the flu vaccine works for older adults aged 65 and up, with the goal of finding ways to better protect those who are more vulnerable.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-10912040

• How the immune system responds to flu shots and flu infection

  This project looks at how adults' immune systems react after flu shots or when they catch the flu to find why some people get better protection than others.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11481644

• Motivational interviewing to increase COVID-19 and flu vaccination

  This project teaches primary care providers conversational skills to help more adults, especially those in vulnerable communities, feel comfortable getting COVID-19 and flu shots.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11412464

• Universal flu vaccine strategy to protect against diverse influenza strains

  A research team is testing new vaccine designs aimed at broad protection against many flu strains for people who want lasting immunity.

  NIH research Rockefeller University · New York, United States · NIH-11384802

• Flu vaccine responses and infection risk in people over 75

  This project looks at immune responses to seasonal flu vaccines in adults over 75 to find patterns linked to protection or risk of infection.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11237598

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.