How FOXO proteins influence stem cell behavior and development
Official title: Regulation of stem cell fate by FOXO and RNA binding proteins
Funded at Central Michigan University · NIH-10653354 · Data updated 2026-11-12
This study looks at how certain proteins help keep stem cells ready to grow and change, even when they're not actively dividing, using tiny worms as a model, which could help us learn more about stem cells in humans.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Central Michigan University NIH-funded |
| Lab location | 1 site (Mount Pleasant, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2023 |
| Award (this year) | $434,505 |
| NIH project number | 1R15GM150082-01 |
| Project ID | NIH-10653354 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in stem cell therapies or those with conditions that could benefit from advancements in regenerative medicine.
✕Less likely to help
Patients with conditions unrelated to stem cell function or those not seeking regenerative treatments may not benefit from this research.
What this research studies
This research investigates the role of FOXO proteins in maintaining stem cell multipotency during periods when cells are not dividing. Using the model organism C. elegans, the study focuses on understanding how these proteins regulate developmental pathways that control cell fate. By examining the quiescent dauer larva stage, researchers aim to uncover the mechanisms that keep stem cells in a multipotent state, which could provide insights applicable to human health. The approach combines genetic analysis with in vivo observations to gain a detailed understanding of stem cell behavior.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing stem cell therapies and improving regenerative medicine.
How similar studies have gone: Other research has shown promising results in understanding stem cell regulation, but this specific approach using C. elegans is relatively novel.
Where this research is happening
-
Central Michigan University
Mount Pleasant, United States Active
Researchers
- Principal investigator: Karp, Xantha — Central Michigan University
- Study coordinator: Karp, Xantha
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.