How fluid flow affects CAR T cell movement and effectiveness in brain tumors
The impact of interstitial fluid flow on CAR T cell trafficking, distribution, and efficacy
This study is looking at how the flow of fluid in brain tumors affects the movement and success of CAR T cells, a special type of treatment for glioblastoma, to help improve how well this therapy works for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Polytechnic Inst and St Univ NIH-funded |
| Lab location | 1 site (Blacksburg, United States) |
| Project ID | NIH-11061781 on NIH RePORTER |
What this research studies
This research investigates how interstitial fluid flow influences the movement and effectiveness of CAR T cells, a type of immunotherapy, in treating glioblastoma, a severe brain cancer. The study aims to understand the relationship between fluid dynamics in the tumor environment and the behavior of CAR T cells, which are engineered to target cancer cells. By identifying factors that affect CAR T cell distribution and efficacy, the research seeks to optimize treatment strategies for better patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma who are considering or undergoing CAR T cell therapy.
Not a fit: Patients with other types of cancer or those who are not eligible for CAR T cell therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved CAR T cell therapies that are more effective in treating glioblastoma.
How similar studies have performed: Other research has shown promising results with CAR T cell therapies in various cancers, indicating potential for success in this novel application.
Where this research is happening
Blacksburg, United States
- Virginia Polytechnic Inst and St Univ — Blacksburg, United States (Active)
Researchers
- Principal investigator: Munson, Jennifer M — Virginia Polytechnic Inst and St Univ
- Study coordinator: Munson, Jennifer M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.