How flu virus molecules and cell proteins help the virus infect people
RNA:protein interactions that dictate the success of influenza virus infection
Researchers are looking at how flu virus pieces and certain human cell proteins team up to help the virus cause infection in people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11372697 on NIH RePORTER |
What this research studies
This work studies the molecular contacts between influenza virus RNAs and host proteins to learn how those interactions change the body’s early immune response. The team focuses on a host protein called IFIT2 that normally fights viruses but appears to be co-opted to help influenza, and on the viral nucleoprotein (NP) that binds host RNAs. Using lab-grown human cells, biochemical mapping of RNA:protein binding, and cell-based infection experiments, they will map which interactions promote or stop virus replication. The findings will guide ideas for new drugs or other ways to block the virus.
Who could benefit from this research
Good fit: People with recent influenza infection who can donate respiratory samples or blood for laboratory analysis would be the most relevant contributors.
Not a fit: Patients seeking an immediate new treatment are unlikely to benefit directly because this is basic laboratory research rather than a clinical trial.
Why it matters
Potential benefit: If successful, this could identify new targets to stop flu virus replication and lead to better antiviral drugs or treatments.
How similar studies have performed: Earlier lab studies have shown IFIT2 and viral NP interact with viral and host RNAs and can change virus growth, but translating these findings into treatments is still new and unproven.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Mehle, Andrew — University of Wisconsin-Madison
- Study coordinator: Mehle, Andrew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.