How filoviruses like Ebola and Marburg interact with the immune system
Intersection Between Viral Translation and Innate Immunity in the Context of Filovirus Infection
This study is looking at specific parts of the Ebola and Marburg virus genes to see how they help the viruses make proteins and avoid being attacked by our immune system, which could lead to new ways to treat these infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10890685 on NIH RePORTER |
What this research studies
This research investigates the role of untranslated regions (UTRs) in the genomes of Ebola and Marburg viruses, focusing on how these regions affect viral protein translation and the immune response. By studying these non-coding sequences, the research aims to uncover mechanisms that allow these viruses to evade the body's innate immune defenses. The approach includes profiling the function of UTRs and examining how they regulate viral gene expression during immune activation. This could lead to a better understanding of filovirus biology and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals at risk of exposure to Ebola or Marburg viruses, particularly in outbreak regions.
Not a fit: Patients who are not at risk of filovirus infections or those with unrelated health conditions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating or preventing severe diseases caused by Ebola and Marburg viruses.
How similar studies have performed: While research on filoviruses is ongoing, the specific focus on untranslated regions as translational regulators is relatively novel and has not been extensively tested.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Basler, Christopher F — Icahn School of Medicine at Mount Sinai
- Study coordinator: Basler, Christopher F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.