How fibrosis in lymph nodes affects T cell function in cancer
Official title: Fibrotic remodeling of lymph nodes disrupts T cell function in fibrosis and cancer
Funded at Harvard University · NIH-11015013 · Data updated 2026-11-12
This study is looking at how scarring in lymph nodes affects T cells, which are important for fighting cancer, and aims to find ways to improve cancer treatments by understanding these changes better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard University NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | January 1, 2024 |
| Project end | May 18, 2025 |
| Funding year | 2025 |
| Award (this year) | $91,945 |
| NIH project number | 5K00CA264411-04 |
| Project ID | NIH-11015013 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with cancer who are experiencing fibrosis in their lymph nodes.
✕Less likely to help
Patients without cancer or those whose lymph nodes are not affected by fibrosis may not benefit from this research.
What this research studies
This research investigates how fibrotic changes in lymph nodes can disrupt the function of T cells, which are crucial for the immune response against cancer. It focuses on understanding the biochemical and mechanical changes in the lymph node environment caused by fibrosis, which can lead to poor immune activation and disease progression. By studying these changes, the research aims to uncover new insights into how to enhance anti-cancer immunotherapy and improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing immune responses in cancer patients, potentially making immunotherapy more effective.
How similar studies have gone: Other research has shown promising results in understanding the role of the lymph node microenvironment in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Harvard University
Cambridge, United States Active
Researchers
- Principal investigator: Bingham, Grace C — Harvard University
- Study coordinator: Bingham, Grace C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.