How fibroblasts influence the immune response in pancreatic cancer
Fibroblast orchestration of the immune response in pancreatic cancer
['FUNDING_U01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10925247
This study is looking at how certain cells in the pancreas, called fibroblasts, work with the immune system in pancreatic cancer, and it aims to find out how these cells can either help or hinder tumor growth, which could lead to new treatments for patients.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10925247 on ClinicalTrials.gov |
What this research studies
This research investigates the role of fibroblasts in pancreatic cancer, focusing on how these cells interact with the immune system and contribute to tumor development. The study aims to understand the diverse functions of fibroblasts, which have been shown to either promote or inhibit tumor growth. By analyzing patient samples, particularly from diverse populations, the research seeks to uncover how genetic variations affect fibroblast behavior and immune response in pancreatic cancer. This could lead to new therapeutic strategies that target these interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with pancreatic cancer, particularly those from diverse racial backgrounds.
Not a fit: Patients with non-cancerous conditions or those not diagnosed with pancreatic cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve outcomes for patients with pancreatic cancer.
How similar studies have performed: Previous research has shown promising results in understanding the role of fibroblasts in other cancers, suggesting potential for success in this novel approach.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PASCA DI MAGLIANO, MARINA — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: PASCA DI MAGLIANO, MARINA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atlas of Cancer Mortality in the United States, Cancer Cause, Cancer Etiology, Cancer Induction, Cancer Maps