How fibroblasts and immune cells interact after brain injury
Official title: Distinct early and late programs of fibroblast - immune crosstalk govern functional responses to brain injury
Funded at University of California, San Francisco · NIH-11129898 · Data updated 2026-11-12
This study is looking at how special cells called fibroblasts help the brain heal and work with immune cells after an injury, using mice to find ways to improve treatments for brain injuries and similar issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | July 2, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $765,176 |
| NIH project number | 5R01AI180438-02 |
| Project ID | NIH-11129898 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced acute brain injuries or are dealing with neuropsychiatric conditions related to brain inflammation.
✕Less likely to help
Patients with chronic, stable neurological conditions that do not involve recent brain injuries may not benefit from this research.
What this research studies
This research investigates the role of fibroblasts, which are important cells for healing and immune regulation, in response to brain injuries. It aims to understand how these cells communicate with immune cells during the early and late stages of brain injury, particularly focusing on their behavior and changes in the central nervous system. By studying mouse models, the research will explore how fibroblasts can influence inflammation and healing processes, potentially leading to better treatments for brain injuries and related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve recovery and outcomes for patients with brain injuries.
How similar studies have gone: Previous research has shown promising results in understanding fibroblast behavior in other tissues, suggesting potential for success in this novel approach to brain injury.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Molofsky, Ari B — University of California, San Francisco
- Study coordinator: Molofsky, Ari B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.