How Fibroblast Growth Factor affects bone cell survival
Regulation of Osteocyte Survival by Fibroblast Growth Factor Signaling Pathways
This study is looking at how a specific signaling process helps bone cells called osteocytes stay healthy, especially as we age or face other challenges that can weaken our bones, with the goal of finding new ways to improve bone health for adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11042164 on NIH RePORTER |
What this research studies
This research investigates the role of Fibroblast Growth Factor (FGF) signaling in the survival of osteocytes, which are crucial for maintaining bone strength and health. The study aims to understand the molecular mechanisms that support osteocyte viability, especially in the context of aging and other factors that lead to bone deterioration. By examining the effects of FGFR signaling on osteocyte survival in animal models, the research seeks to uncover potential therapeutic targets for improving bone health in adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults experiencing age-related bone health issues or conditions that affect osteocyte survival.
Not a fit: Patients with acute bone injuries or those not experiencing age-related bone decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance bone health and reduce the risk of fractures in aging populations.
How similar studies have performed: Previous research has shown promising results in understanding the role of signaling pathways in bone health, indicating that this approach has potential for success.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Ornitz, David M — Washington University
- Study coordinator: Ornitz, David M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.