How fibrin and neutrophils interact in gum disease
Official title: Fibrin-neutrophil interaction in periodontitis immunopathology
Funded at Harvard Medical School · NIH-10928824 · Data updated 2026-11-12
This study is looking at how certain immune system components, like fibrin and neutrophils, affect gum disease, especially in young people with a rare condition called ligneous periodontitis, to better understand why it causes serious oral health problems like tooth loss and how we can help.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $242,721 |
| NIH project number | 5R00DE030124-03 |
| Project ID | NIH-10928824 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adolescents with genetic predispositions to gum disease, particularly those with conditions like Plasminogen deficiency.
✕Less likely to help
Patients without genetic factors contributing to gum disease or those with unrelated oral health issues may not benefit from this research.
What this research studies
This research investigates the role of fibrin and neutrophils in the immune response related to gum disease, particularly focusing on a condition known as ligneous periodontitis. It aims to understand how disruptions in mucosal immunity can lead to severe oral health issues, including significant bone loss and tooth loss in adolescents. By studying patients with specific genetic mutations, the research seeks to uncover the mechanisms behind these conditions and how they can be addressed. The approach includes analyzing immune responses and fibrin deposition in oral tissues.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for gum disease that significantly improve oral health and prevent tooth loss in affected individuals.
How similar studies have gone: Previous research has shown promising results in understanding the immune mechanisms involved in oral diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Harvard Medical School
Boston, United States Active
Researchers
- Principal investigator: Silva, Munasinghage Lakmali — Harvard Medical School
- Study coordinator: Silva, Munasinghage Lakmali
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.