How FGF18 affects lung development after birth
FGF18 regulation of postnatal lung development
This study is looking at how a protein called FGF18 helps the lungs grow properly after babies are born, especially for premature infants with a condition called bronchopulmonary dysplasia (BPD), to find new ways to help their lungs work better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10703208 on NIH RePORTER |
What this research studies
This research investigates the role of FGF18 in the development of the lungs after birth, particularly focusing on a condition known as bronchopulmonary dysplasia (BPD), which often affects premature infants. The study aims to understand how FGF18 influences the formation of alveoli, the tiny air sacs in the lungs that are crucial for breathing. By examining the cellular processes involved in lung development, the research seeks to identify potential therapies that could improve lung function in infants suffering from BPD and possibly aid in lung regeneration in adults. The approach includes detailed analysis of lung tissue and cellular interactions during the critical phases of alveologenesis.
Who could benefit from this research
Good fit: Ideal candidates for this research are premature infants diagnosed with bronchopulmonary dysplasia.
Not a fit: Patients who are not premature or do not have bronchopulmonary dysplasia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve lung development and function in infants with bronchopulmonary dysplasia.
How similar studies have performed: Other research has shown promise in understanding lung development and potential therapies for similar conditions, making this approach both relevant and potentially impactful.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Ornitz, David M — Washington University
- Study coordinator: Ornitz, David M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.