How fentanyl dependence affects brain circuits involved in pain and emotion
Impact of fentanyl dependence on a parabrachio-amygdalar opioid circuit
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF PENNSYLVANIA · NIH-10988267
This study is looking at how being dependent on fentanyl affects certain parts of the brain that deal with pain and emotions, to help find better ways to treat pain without the negative side effects of opioids.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10988267 on ClinicalTrials.gov |
What this research studies
This research investigates the effects of fentanyl dependence on specific brain circuits that are involved in pain perception and emotional responses. By examining how prolonged use of fentanyl alters the functioning of neurons in the parabrachial nucleus and the central amygdala, the study aims to identify the mechanisms that lead to increased pain sensitivity and dependence. The approach includes detailed analysis of neural pathways and cell types that may contribute to opioid-induced hyperalgesia and withdrawal symptoms. This research could lead to new treatment strategies that maintain the benefits of opioids while reducing their harmful effects.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are currently using fentanyl for pain management and may be experiencing signs of dependence.
Not a fit: Patients who are not using opioids or those who do not have chronic pain conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved pain management strategies that minimize the risk of opioid dependence and enhance patient quality of life.
How similar studies have performed: Previous research has shown promising results in understanding opioid dependence and its effects on brain circuits, suggesting that this approach could yield valuable insights.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WOOLDRIDGE, LISA — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: WOOLDRIDGE, LISA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.