How female sex influences the resilience of blood vessel cells to oxidative stress after a stroke
Female sex protects vascular smooth muscle cells from mitochondrial depolarization to oxidative stress
This study is looking at why female cells in blood vessels seem to handle stress from a stroke better than male cells, with the hope of finding new ways to help everyone recover better after a stroke.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-11003279 on NIH RePORTER |
What this research studies
This research investigates how female vascular smooth muscle cells are better protected from damage caused by oxidative stress following a stroke compared to male cells. It focuses on understanding the mechanisms behind this protection, particularly in relation to mitochondrial function and calcium signaling. By exploring these sex-based differences, the study aims to identify potential therapeutic targets that could improve recovery after ischemic strokes. Patients may benefit from insights that could lead to more effective treatments tailored to their biological sex.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced an ischemic stroke, particularly those interested in understanding sex-based differences in recovery.
Not a fit: Patients who have not experienced a stroke or those with conditions unrelated to vascular health may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for stroke recovery that leverage the protective mechanisms found in female vascular cells.
How similar studies have performed: Previous research has shown that sex differences can influence cellular responses to stress, suggesting that this approach may yield valuable insights.
Where this research is happening
Columbia, United States
- University of Missouri-Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Norton, Charles E — University of Missouri-Columbia
- Study coordinator: Norton, Charles E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.