How fatty acids affect the immune response to brain tumors after radiation therapy
Fatty Acid Metabolic Regulation of Anti-Tumor Immunity Against Irradiated Glioblastoma
This study is looking at how glioblastoma, a tough brain tumor, can resist treatments like radiation therapy, and it aims to find ways to boost the immune system's ability to fight the cancer by understanding the changes in fatty acids produced by the tumor after treatment, so it’s designed for patients who are receiving radiation therapy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11088157 on NIH RePORTER |
What this research studies
This research investigates how glioblastoma, a severe brain tumor, develops resistance to treatments like radiation therapy. It focuses on the role of fatty acids produced by tumor cells after radiation, which may hinder the immune system's ability to fight the cancer. By understanding these metabolic changes, the research aims to find ways to enhance the body's anti-tumor immune response, potentially improving treatment outcomes for patients. The study will involve analyzing immune responses and tumor metabolism in patients undergoing radiation therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with glioblastoma who are undergoing radiation therapy.
Not a fit: Patients with glioblastoma who are not receiving radiation therapy or those with other types of brain tumors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies that enhance the immune response against glioblastoma, potentially increasing survival rates.
How similar studies have performed: Other research has shown promising results in enhancing anti-tumor immunity through metabolic interventions, suggesting potential success for this approach.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Vanpouille-Box, Claire Isabelle — Weill Medical Coll of Cornell Univ
- Study coordinator: Vanpouille-Box, Claire Isabelle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.