How fatty acids affect the immune response to brain tumors after radiation therapy
Official title: Fatty Acid Metabolic Regulation of Anti-Tumor Immunity Against Irradiated Glioblastoma
Funded at Weill Medical Coll of Cornell Univ · NIH-11088157 · Data updated 2026-11-12
This study is looking at how glioblastoma, a tough brain tumor, can resist treatments like radiation therapy, and it aims to find ways to boost the immune system's ability to fight the cancer by understanding the changes in fatty acids produced by the tumor after treatment, so it’s designed for patients who are receiving radiation therapy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $530,531 |
| NIH project number | 5R01NS131945-03 |
| Project ID | NIH-11088157 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with glioblastoma who are undergoing radiation therapy.
✕Less likely to help
Patients with glioblastoma who are not receiving radiation therapy or those with other types of brain tumors may not benefit from this research.
What this research studies
This research investigates how glioblastoma, a severe brain tumor, develops resistance to treatments like radiation therapy. It focuses on the role of fatty acids produced by tumor cells after radiation, which may hinder the immune system's ability to fight the cancer. By understanding these metabolic changes, the research aims to find ways to enhance the body's anti-tumor immune response, potentially improving treatment outcomes for patients. The study will involve analyzing immune responses and tumor metabolism in patients undergoing radiation therapy.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies that enhance the immune response against glioblastoma, potentially increasing survival rates.
How similar studies have gone: Other research has shown promising results in enhancing anti-tumor immunity through metabolic interventions, suggesting potential success for this approach.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Vanpouille-Box, Claire Isabelle — Weill Medical Coll of Cornell Univ
- Study coordinator: Vanpouille-Box, Claire Isabelle
Related research
Other NIH-funded projects on the same topics.
-
Small molecules to block Slit2/ROBO in glioblastoma
A study to test small molecule drugs that block Slit2/ROBO signals to help treat glioblastoma in patients.
-
Immunotherapy for glioblastoma: advancing treatment and understanding
A patient-friendly summary of a grant exploring new immune-based treatments for glioblastoma to improve options for people affected by this brain cancer.
-
Small-molecule and biologic treatments for glioblastoma using targeted brain delivery
A new approach aims to use FPS-ZM1 to shrink brain swelling and support immunotherapy for glioblastoma, potentially helping patients recover after surgery.
-
Targeted therapies for glioblastoma in adults and kids
A large NIH program is exploring new brain cancer therapies, including drugs that reach the brain and work against glioblastoma in both children and adults.
-
6-thio-2'-deoxyguanosine for glioblastoma: a new approach to target tumors before surgery
A trial tests a novel drug given before glioblastoma surgery to see how it behaves in the body and within the tumor, and to learn how it affects cancer cells and the immune environment.
-
CD38-Driven Changes in Brain Tumor Metabolism and Immunity in Glioblastoma
A patient-facing look at how scientists plan to study how glioblastoma grows by changing its metabolism and dampening the immune response, with potential targets to help treatment in the future.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.