How fatty acids affect the immune response in lung cancer
Regulation of the innate immune response in the tumor microenvironment of lung adenocarcinoma
This study is looking at how certain healthy fats, called monounsaturated fatty acids, might affect lung cancer and the immune system's ability to fight it, especially for patients who don't respond well to standard treatments.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-10884277 on NIH RePORTER |
What this research studies
This research investigates the role of monounsaturated fatty acids (MUFA) in lung adenocarcinoma and how they influence the immune response within tumors. It aims to understand why some lung cancer patients do not respond to common immunotherapies by examining the secretion of a protein called HMGB1, which can suppress immune activity. The study will involve analyzing patient samples to correlate MUFA levels with HMGB1 expression and using laboratory models to observe how MUFA affects tumor behavior and immune cell interactions. By identifying these mechanisms, the research seeks to uncover new strategies to enhance immune responses in lung cancer patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are lung cancer patients, particularly those who have not responded well to existing immunotherapies.
Not a fit: Patients with lung cancer who have already shown a robust immune response to treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for lung cancer patients by enhancing their immune response against tumors.
How similar studies have performed: While the specific approach of examining MUFA in lung cancer is novel, similar studies have shown that manipulating the tumor microenvironment can enhance immune responses in other cancers.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Simmons, Glenn Edward — Cornell University
- Study coordinator: Simmons, Glenn Edward
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.