How fatty acid modifications affect heart cell signaling and disease progression
Official title: S-acylation-dependent regulation of cytokine receptor signaling and cardiac maladaptation
Funded at University of Michigan at Ann Arbor · NIH-11001525 · Data updated 2026-11-12
This study is looking at how a process called S-acylation affects heart cells and their response to signals that can lead to heart problems, with the hope of finding new ways to help improve heart health for people at risk of heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $432,824 |
| NIH project number | 5R01HL166274-03 |
| Project ID | NIH-11001525 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are at risk for or currently experiencing heart disease.
✕Less likely to help
Patients with non-cardiac conditions or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the role of S-acylation, a process where fatty acids attach to proteins, in regulating how heart cells respond to signals that can lead to heart disease. By studying this mechanism, the researchers aim to understand how inflammatory signals from immune cells affect heart function and contribute to conditions like heart failure. The approach involves using advanced techniques to analyze protein modifications in heart cells, particularly focusing on the Jak-Stat signaling pathway, which is crucial during cardiac stress. The findings could reveal new targets for therapies aimed at improving heart health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage or prevent heart disease by targeting specific signaling pathways in heart cells.
How similar studies have gone: Previous research has shown that targeting specific signaling pathways can lead to significant advancements in heart disease treatment, suggesting that this approach may also yield promising results.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Brody, Matthew Jacob — University of Michigan at Ann Arbor
- Study coordinator: Brody, Matthew Jacob
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.