How fatty acid metabolism affects lung repair in aging and fibrosis
Official title: Regulation of Repair Responses in the Lung by Fatty Acid Oxidation
Funded at Ohio State University · NIH-11118810 · Data updated 2026-11-12
This study is looking at how the way our bodies use fats might help heal lung tissue in people with Idiopathic Pulmonary Fibrosis (IPF), a lung disease that gets worse over time, to see if improving fat metabolism can boost lung repair and function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | June 17, 2024 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $696,377 |
| NIH project number | 5R01HL172490-02 |
| Project ID | NIH-11118810 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults or individuals diagnosed with Idiopathic Pulmonary Fibrosis.
✕Less likely to help
Patients with acute lung injuries unrelated to aging or fibrosis may not benefit from this research.
What this research studies
This research investigates the role of fatty acid oxidation in the repair processes of lung tissue, particularly in the context of Idiopathic Pulmonary Fibrosis (IPF), a progressive lung disease often associated with aging. The study focuses on understanding how the metabolism of fatty acids influences the behavior of specific lung cells, known as alveolar epithelial type II cells, which are crucial for lung repair. By using specialized cell lines and mouse models, researchers aim to uncover the mechanisms that lead to lung fibrosis and how enhancing fatty acid metabolism might improve lung function and repair.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance lung repair and function in patients with age-related lung diseases.
How similar studies have gone: Previous research has shown promising results in understanding the role of fatty acid metabolism in other tissues, suggesting potential for success in this novel approach to lung repair.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Mora, Ana Lucia — Ohio State University
- Study coordinator: Mora, Ana Lucia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.