How fatty acid metabolism affects cell death in lung cancer with mutant KRAS
Fatty acid metabolism regulates ferroptosis in mutant KRAS lung cancer
This study is looking at how the way cancer cells use fats affects the growth of lung cancer caused by a common mutation, with the goal of finding new ways to help treat patients with this tough type of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11001455 on NIH RePORTER |
What this research studies
This research investigates the role of fatty acid metabolism in lung cancer driven by mutant KRAS, a common mutation found in non-small cell lung cancer. The study aims to understand how changes in lipid metabolism contribute to the survival and growth of cancer cells. By analyzing the lipid profiles of cancer cells and using advanced imaging techniques, researchers hope to identify new therapeutic targets that could improve treatment outcomes for patients with this aggressive form of lung cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with non-small cell lung cancer that has the KRAS mutation.
Not a fit: Patients with lung cancer that does not have the KRAS mutation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that specifically target metabolic pathways in mutant KRAS lung cancer, potentially improving survival rates.
How similar studies have performed: Other research has shown promising results in targeting metabolic pathways in cancer, suggesting that this approach could be effective.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Scaglioni, Pier Paolo — University of Cincinnati
- Study coordinator: Scaglioni, Pier Paolo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.