How fats in cell membranes change brain ion channel function
Lipid Modulation of Ligand-Gated Ion Channels
Researchers are learning how fats in brain cell membranes alter the opening and closing of key ion channels that affect brain signaling and responses to drugs.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11091081 on NIH RePORTER |
What this research studies
This project uses high-resolution imaging and laboratory tests to see how membrane lipids influence pentameric ligand-gated ion channels, proteins that help nerve cells communicate. The team will combine cryo-electron microscopy with functional measurements in artificial membranes, pulsed-EPR, and computer simulations to capture intermediate channel states. They will study a model bacterial channel and then apply lessons to a human version of the channel. The lab work focuses on defined liposome membranes so researchers can link specific lipids to changes in channel behavior.
Who could benefit from this research
Good fit: This project does not enroll patients; it is laboratory research on purified proteins and model membranes conducted at the university.
Not a fit: Patients should not expect direct clinical benefit or enrollment opportunities from this grant, since it does not run clinical trials or patient interventions.
Why it matters
Potential benefit: If successful, the work could clarify how membrane lipids shape ion channel activity and inform safer, more targeted drugs for brain conditions and anesthesia.
How similar studies have performed: Prior structural and functional studies have shown lipid effects on model channels, but applying cryo-EM and functional assays in defined liposomes to human channels is a newer, less-tested step.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Cheng, Wayland Wing-Lun — Washington University
- Study coordinator: Cheng, Wayland Wing-Lun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.