How fat tissue contributes to pancreatic cancer development
Official title: Contributions of the Adipose Tissue to the Development of Pancreatic Cancer
Funded at Ohio State University · NIH-11031398 · Data updated 2026-11-12
This study is looking at how extra body fat might affect the growth of pancreatic cancer and how well patients do, using special mice to understand the links between obesity and cancer, with the hope of finding new ways to prevent and treat this disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | February 8, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $523,133 |
| NIH project number | 5R01CA279707-02 |
| Project ID | NIH-11031398 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are obese and at risk for pancreatic ductal adenocarcinoma.
✕Less likely to help
Patients who are not obese or do not have a risk of developing pancreatic cancer may not benefit from this research.
What this research studies
This research investigates the role of adipose tissue in the development of pancreatic cancer, particularly focusing on how obesity influences tumor growth and patient survival. The study uses genetically engineered mouse models to explore the mechanisms by which obesity-related inflammation and metabolic changes promote cancer progression. By examining specific molecules like lipocalin 2 and fatty acids, the research aims to uncover potential pathways that could be targeted for better prevention and treatment strategies for pancreatic cancer.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment options for pancreatic cancer patients, particularly those affected by obesity.
How similar studies have gone: Previous research has shown promising results in understanding the relationship between obesity and pancreatic cancer, indicating that this approach has potential for significant findings.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Cruz-Monserrate, Zobeida — Ohio State University
- Study coordinator: Cruz-Monserrate, Zobeida
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.