How fat tissue changes can improve metabolic health
Post-translational control of adipose tissue remodeling and metabolic health
This study is looking at how changing white fat into healthier brown or beige fat can help improve metabolic health, especially for people dealing with obesity and type 2 diabetes, and it aims to find safer ways to do this without the side effects of current treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10645148 on NIH RePORTER |
What this research studies
This research investigates how the remodeling of fat tissue, particularly the transformation of white fat into brown or beige fat, can enhance metabolic health. By understanding the biological processes involved in fat tissue adaptation, the study aims to identify new pathways that stimulate this transformation without the side effects associated with current treatments. The research utilizes various methodologies, including animal models, to explore the effects of different stimuli on fat tissue and metabolic regulation. Ultimately, the goal is to find safer and more effective ways to improve conditions like obesity and type 2 diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals struggling with obesity or type 2 diabetes who may benefit from improved metabolic health.
Not a fit: Patients with metabolic disorders unrelated to adipose tissue remodeling may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve metabolic health and reduce the risk of diabetes and obesity-related complications.
How similar studies have performed: Previous research has shown promise in similar approaches, but this study aims to explore novel pathways that have not been extensively tested.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Kajimura, Shingo — Beth Israel Deaconess Medical Center
- Study coordinator: Kajimura, Shingo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.