How fat tissue around blood vessels affects heart health
Regulation of arterial phenotype by perivascular adipose tissue in cardiometabolic disease
This study is looking at how certain types of fat around blood vessels can affect heart health, especially in people with obesity-related heart issues, to find new ways to help the body burn fat and improve blood vessel function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mainehealth NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10887392 on NIH RePORTER |
What this research studies
This research investigates the role of perivascular adipose tissue (PVAT) in cardiovascular diseases, particularly how different types of fat cells influence blood vessel function. The study focuses on understanding the molecular characteristics of these fat cells, especially their thermogenic properties, which may protect against vascular diseases. By comparing healthy and diseased human tissues, the research aims to uncover potential therapeutic strategies that could enhance the body's ability to burn fat and improve heart health. Patients may benefit from insights that could lead to new treatments for obesity-related cardiovascular conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with obesity or cardiometabolic diseases who are at risk for cardiovascular issues.
Not a fit: Patients without obesity or cardiovascular risk factors may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve heart health by targeting fat tissue around blood vessels.
How similar studies have performed: Other research has shown promising results in understanding the role of adipose tissue in cardiovascular health, suggesting that this approach could lead to significant advancements.
Where this research is happening
Portland, United States
- Mainehealth — Portland, United States (Active)
Researchers
- Principal investigator: Liaw, Lucy — Mainehealth
- Study coordinator: Liaw, Lucy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.