How fat tissue affects tuberculosis and diabetes interactions
Immunometabolic regulations of pulmonary TB pathogenesis by adiposetissue
This study is looking at how body fat affects the risk of getting tuberculosis (TB) in people with type 2 diabetes, and it wants to find out if losing weight can help improve their immune response to the infection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hackensack University Medical Center NIH-funded |
| Lab location | 1 site (Hackensack, United States) |
| Project ID | NIH-10754897 on NIH RePORTER |
What this research studies
This research investigates the complex relationship between adipose tissue and the progression of pulmonary tuberculosis (TB) in individuals with type 2 diabetes mellitus (T2DM). It aims to understand how fat cells influence immune responses and TB pathogenesis, particularly focusing on the role of adiponectin, an anti-inflammatory substance produced by fat cells. By examining the effects of fat loss and the presence of adipocytes on TB infection, the study seeks to uncover the molecular mechanisms that link obesity and diabetes to TB risk. Patients may be involved in understanding how their body fat impacts their susceptibility to TB.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of tuberculosis infection, particularly those who also have type 2 diabetes or obesity.
Not a fit: Patients without a history of tuberculosis infection or those who do not have diabetes or obesity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating tuberculosis in patients with diabetes and other related conditions.
How similar studies have performed: Previous research has shown promising results in understanding the interactions between obesity and immune responses in infectious diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Hackensack, United States
- Hackensack University Medical Center — Hackensack, United States (Active)
Researchers
- Principal investigator: Nagajyothi, Jyothi Falguni — Hackensack University Medical Center
- Study coordinator: Nagajyothi, Jyothi Falguni
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.