How fat tissue affects immune cell behavior and blood pressure
Regulation of immune cell function by the PVAT microenvironment
This study is looking at how fat tissue around blood vessels affects immune cells, especially T cells, in people who are dealing with obesity and high blood pressure, to find new ways to help manage these conditions.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-10980462 on NIH RePORTER |
What this research studies
This research investigates the role of perivascular adipose tissue (PVAT) in regulating immune cell function, particularly focusing on how this tissue influences T cell activity in the context of obesity and hypertension. By examining the immune cell populations in PVAT, the study aims to understand how a high-fat diet alters immune responses and contributes to high blood pressure. The researchers will utilize various methodologies, including RNA sequencing and immune cell assays, to explore the interactions between adipose tissue and immune cells. This work is crucial for identifying potential therapeutic targets for managing hypertension related to obesity.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are experiencing obesity or hypertension.
Not a fit: Patients who are not overweight or do not have hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating hypertension and related cardiovascular diseases in obese individuals.
How similar studies have performed: Previous research has shown that immune cell interactions with adipose tissue can influence metabolic diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
East Lansing, United States
- Michigan State University — East Lansing, United States (Active)
Researchers
- Principal investigator: Rockwell, Cheryl Elizabeth — Michigan State University
- Study coordinator: Rockwell, Cheryl Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.