How fat tissue affects heart health through gene expression
Post-transcriptional control of adipose tissue gene expression as an endocrine mediator of cardiac pathology
This study looks at how fat in our bodies, especially a type called brown fat, affects heart health and could lead to heart problems, helping us understand how being overweight might impact your heart.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11046837 on NIH RePORTER |
What this research studies
This research investigates the role of adipose tissue, or fat, as an endocrine organ that influences heart health. It focuses on understanding how changes in fat tissue, particularly brown fat, affect cardiac function and contribute to cardiovascular diseases. The study examines the mechanisms behind these effects, including the role of specific proteins that regulate gene expression in fat cells. By exploring these connections, the research aims to uncover new insights into how obesity impacts heart health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with obesity, particularly those who may have cardiovascular issues or are at risk for heart disease.
Not a fit: Patients who are not overweight or do not have any cardiovascular risk factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cardiovascular diseases related to obesity.
How similar studies have performed: Other research has shown promising results in understanding the relationship between adipose tissue and cardiovascular health, indicating that this approach has potential for significant findings.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Tranter, Michael — Ohio State University
- Study coordinator: Tranter, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.