How fat cells communicate to control inflammation and insulin sensitivity
Official title: Adipocyte cytokine signaling as a coordinator of adipose tissue function
Funded at Lsu Pennington Biomedical Research Ctr · NIH-10811230 · Data updated 2026-11-12
This study is looking at how a substance called oncostatin M, made by immune cells in fat tissue, influences inflammation and insulin sensitivity in people with obesity, with the goal of finding new ways to help manage obesity-related health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Pennington Biomedical Research Ctr NIH-funded |
| Lab location | 1 site (Baton Rouge, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $350,000 |
| NIH project number | 1R01DK134469-01A1 |
| Project ID | NIH-10811230 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are obese and experiencing insulin resistance or related metabolic disorders.
✕Less likely to help
Patients who are not obese or do not have metabolic disorders may not benefit from this research.
What this research studies
This research investigates the role of adipocyte (fat cell) signaling in regulating inflammation and insulin sensitivity in the context of obesity. It focuses on a specific cytokine called oncostatin M (OSM), which is produced by immune cells in adipose tissue. The study aims to understand how OSM signaling affects adipocyte function and inflammation, potentially leading to better management of obesity-related conditions. By exploring the mechanisms of adipocyte regulation, the research seeks to uncover new therapeutic targets for improving metabolic health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve insulin sensitivity and reduce inflammation in obese patients.
How similar studies have gone: Previous research has shown promising results in understanding cytokine signaling in adipose tissue, suggesting that this approach could lead to significant advancements in obesity treatment.
Where this research is happening
-
Lsu Pennington Biomedical Research Ctr
Baton Rouge, United States Active
Researchers
- Principal investigator: Elks, Carrie M — Lsu Pennington Biomedical Research Ctr
- Study coordinator: Elks, Carrie M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.