How fat cells and immune cells interact to affect asthma symptoms
Official title: Adipocyte-Eosinophil Communication and Its Role in Regulation of Airway Function
Funded at University of Colorado Denver · NIH-11130293 · Data updated 2026-11-12
This study is looking at how fat cells and a type of immune cell called eosinophils talk to each other and affect breathing and inflammation in people with asthma, especially those who are overweight, to find new ways to help manage asthma symptoms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | June 17, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $730,392 |
| NIH project number | 1R01AI184705-01A1 |
| Project ID | NIH-11130293 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with asthma, particularly those who are also obese or overweight.
✕Less likely to help
Patients with asthma who are not overweight or obese may not benefit directly from the findings of this research.
What this research studies
This research investigates the communication between fat cells and eosinophils, a type of immune cell, to understand how they influence airway function and inflammation in asthma patients. By studying both lean and obese mice, the researchers aim to uncover the mechanisms that link obesity with worsening asthma symptoms. The study will explore how these interactions can lead to better therapeutic strategies for managing asthma, particularly in individuals with obesity. Patients may benefit from insights that could lead to new treatments targeting these cellular interactions.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve asthma management for patients, especially those who are also struggling with obesity.
How similar studies have gone: Previous research has shown promising results in understanding the role of adipose tissue in asthma, but this specific approach to studying eosinophil interactions is relatively novel.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Berdnikovs, Sergejs — University of Colorado Denver
- Study coordinator: Berdnikovs, Sergejs
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.